As HIV becomes a more manageable disease, the difference in severity between its outcome and that of other sexually transmitted infections (STIs) also decreases. Syphilis, hepatitis C, and human papilloma virus (HPV) all pose serious health risks. Syphilis can damage the heart, the brain, and nervous system. From 1996 to 2016, diagnoses of infectious syphilis in Broward increased by 906 percent. Hep C can lead to liver cancer. HPV can lead to anal cancer. All can lead to death.