Italian fashion designers Domenico Dolce and Stefano Gabbana have outraged gays with their comments regarding family structure.

In an interview with the Italian magazine Panorama, the partners stated their opposition to same-sex parenting. They are quoted as saying: “We oppose gay adoptions. The only family is the traditional one. No chemical offspring and rented uterus: life has a natural flow. There are things that should not be changed.”

Dolce and Gabbana are gay men who were in a relationship but have since separated but still jointly own and operate their fashion line. Their comments produced much outrage over the weekend and a swift response from gay couples with adopted children.

British music icon, Sir Elton John, led the pushback against D&G.

“How dare you refer to my beautiful children as synthetic,” John wrote on his Instagram account.

John and husband David Furnish have two adopted boys via a surrogate mother. John called for an immediately boycott of the D&G label.

“Shame on you for wagging your judgmental little fingers at IVF – a miracle that has allowed legions of loving people, both straight and gay, to fulfil their dream of having children. Your archaic thinking is out of step with the times, just like your fashions. I shall never wear Dolce and Gabbana ever again.”

John concluded his outrage with the hashtag, #BoycottDolceGabbana

Dolce states he is a practicing Roman Catholic. In defense of their partnership, Gabbana called John, a “fascist.” Gabbana is also urging his followers to boycott John’s music.